48 papers
This study developed and validated a novel machine learning-derived cumulative risk score that effectively stratifies trial of labor after cesarean (TOLAC) candidates by predicting both vaginal birth success and neonatal morbidity, while confirming that uterine rupture remains unpredictable by antepartum factors.
This cross-sectional study at Moi Teaching and Referral Hospital in Kenya found that while the majority of singleton breech deliveries were managed via emergency caesarean section, a significant portion still underwent vaginal delivery, resulting in notable rates of birth complications (approximately 15%) and severe perineal tears (40%) among the mothers.
This five-year longitudinal study in Sierra Leone reveals that while modern contraceptive use among post-caesarean women reaches 48.5% at five years, it is significantly influenced by increased health system contact, specifically higher antenatal care attendance and receiving contraceptive offers before discharge, whereas delivery at tertiary facilities is associated with lower uptake.
This national study reveals that pregnancy-associated overdose and substance use disorder mortality follow a distinct geographic pattern from all-cause maternal mortality, characterized by a convergence of overdose rates across rural and urban areas during the pandemic, a dominance of substance use disorder deaths over acute overdoses, and a concentration of fatalities in the late postpartum period, highlighting the need for integrated addiction care and extended postpartum support.
This study demonstrates that a new predictive model integrating clinical factors, parity-specific data, and molecular biomarkers significantly outperforms the existing PreTRM test and standard risk predictors in accurately forecasting spontaneous preterm birth and associated neonatal hospital stays in asymptomatic women.
This Phase 2b randomized trial conducted in South Africa demonstrates that combining loop electrosurgical excision procedure (LEEP) with adjuvant intravaginal 5-fluorouracil is an acceptable and feasible treatment for cervical precancer in women living with HIV, supporting its advancement to a Phase 3 trial despite a higher incidence of mild inflammatory side effects.
This study demonstrates that machine learning models trained on vaginal microbiome data predict bacterial vaginosis less accurately in HIV-positive Tanzanian women compared to HIV-negative cohorts, highlighting the need for population-specific diagnostic tools that account for distinct microbial communities associated with HIV status.
Based on a cohort analysis of over 15,000 women in four countries, this study demonstrates that severe anaemia significantly increases the risk of postpartum shock independent of blood loss volume, highlighting the critical need for public health interventions to prevent and treat anaemia in women of reproductive age.
This study demonstrates that a wearable near-infrared spectroscopy device combined with machine learning analysis can accurately predict adverse pregnancy outcomes by utilizing dynamic metabolic and hemodynamic signals, rather than static oxygenation levels, to monitor placental function in high-risk pregnancies.
This study demonstrates that a first-trimester multi-modal, tissue-resolved circulating cell-free DNA (cfDNA) analysis derived from routine non-invasive prenatal testing samples enables accurate early prediction of both preterm and term preeclampsia, offering superior discrimination for term disease compared to the standard Fetal Medicine Foundation screening model.
This Chilean population-based study utilizes multivariate analysis to demonstrate that Autism Spectrum Disorder is associated with a structured pattern of perinatal risks—specifically maternal vaginal bleeding, prenatal stress, and negative pregnancy perception—rather than isolated factors, highlighting the need for integrated obstetric and mental health care.
This prospective study across three sub-Saharan African countries provides exploratory evidence that higher personal exposure to PM2.5 air pollution is significantly associated with impaired fetal growth and lower birthweight centiles, though no direct links were found with pregnancy hypertension, preterm delivery, or stillbirth.
This prospective cohort study reveals that endometriosis comprises partially independent dimensions where pain severity and quality of life are driven by neuroinflammatory mechanisms rather than anatomical staging, while fertility outcomes and organ-threatening complications are primarily determined by structural disease burden.
This study reveals that informed consent and post-operative debriefing for caesarean sections in West Cameroon are characterized by systemic injustices and unfairness, including informational deficits, cultural insensitivity, and the default absence of debriefing, which disproportionately disadvantage rural, low-income, and less educated women.
This retrospective cohort study demonstrates that using hyaluronan-enriched transfer medium significantly increases live birth rates compared to standard medium for euploid blastocysts that have undergone trophectoderm biopsy, likely by enhancing embryo-endometrial interaction through zona pellucida disruption.
This study introduces and validates the Preterm Birth Actionable Risk Index (PTB-ARIx), a predictive tool based on 1.9 million California births that identifies individuals at high risk for preterm birth by focusing on modifiable risk factors with evidence-based interventions, thereby offering a pathway to improve targeted care and reduce adverse pregnancy outcomes.
This study reveals that semaglutide exerts compartment-specific effects on the human embryo-endometrium interface by enhancing epithelial receptivity and embryonic metabolic activity while simultaneously disrupting stromal decidualization, potentially compromising implantation support.
This cross-sectional study of 500 pregnant women in Jordan reveals that nearly half possess inadequate knowledge about urinary tract infections, with significantly lower awareness observed among older, rural, less-educated, and unemployed women, highlighting the need for targeted health education within antenatal care.
This prospective cohort study demonstrates that prenatal cannabis exposure is independently associated with reduced birthweight and an increased risk of being small for gestational age, with these adverse effects significantly intensified when combined with nicotine exposure.
This prospective study reveals that maternal trait anxiety is associated with increased placental diffusivity indicating altered microstructure, while mothers carrying fetuses with congenital heart disease exhibit higher levels of anxiety and depressive symptoms, though the presence of the heart defect does not modify the relationship between stress and placental measures.